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1

Synthesis and Enzymatic Deprotection of Biodegradably Protected Dinucleoside-2′,5′-monophosphates: 3-(Acetyloxy)-2,2-bis(ethoxycarbonyl)propyl Phosphoesters of 3′-O-(Acyloxymethyl)adenylyl-2′,5′-adenosines

Emilia Kiuru, Mikko Ora, Leonid Beigelman, Lawrence Blatt, Harri Lönnberg

Journal:

Chemistry & Biodiversity

Year:

2011

Language:

english

File:

PDF, 308 KB

english, 2011

2

Synthesis and Enzymatic Deprotection of Fully Protected 2′-5′ Oligoadenylates (2-5A): Towards a Prodrug Strategy for Short 2-5A

Emilia Kiuru, Mikko Ora, Leonid Beigelman, Lawrence Blatt, Harri Lönnberg

Journal:

Chemistry & Biodiversity

Year:

2012

Language:

english

File:

PDF, 561 KB

english, 2012

3

A Practical Synthesis of 3′-Thioguanosine and of Its 3′-Phosphoramidothioite (a Thiophosphoramidite)

Jasenka Matulic-Adamic, Leonid Beigelman

Journal:

Helvetica Chimica Acta

Year:

1999

Language:

english

File:

PDF, 129 KB

english, 1999

4

ChemInform Abstract: A Practical Synthesis of 3′-Thioguanosine and of Its 3′-Phosphoramidothioite (a Thiophosphoramidite).

Jasenka Matulic-Adamic, Leonid Beigelman

Journal:

Year:

2000

File:

PDF, 24 KB

2000

5

ChemInform Abstract: Improved Synthetic Approaches Toward 2′-O-Methyl Adenosine and Guanosine and Their N-Acyl Derivatives.

Leonid Beigelman, Peter Haeberli, David Sweedler, Alexander Karpeisky

Journal:

Year:

2000

File:

PDF, 36 KB

2000

6

ChemInform Abstract: Functionalized Nucleoside 5′-Triphosphates for in vitro Selection of New Catalytic Ribonucleic Acids.

Jasenka Matulic-Adamic, Andrew T. Daniher, Alexander Karpeisky, Peter Haeberli, David Sweedler, Leonid Beigelman

Journal:

Year:

2000

File:

PDF, 32 KB

2000

7

ChemInform Abstract: An Improved Synthesis of Inosine 3′-Phosphoramidite.

Jasenka Matulic-Adamic, Leonid Beigelman

Journal:

Year:

2001

File:

PDF, 27 KB

2001

8

ChemInform Abstract: Synthesis of Modified Nucleoside 5′-Triphosphates for in vitro Selection of Catalytic Nucleic Acids

Jasenka Matulic-Adamic, Andrew T. Daniher, Alexander Karpeisky, Peter Haeberli, David Sweedler, Leonid Beigelman

Journal:

Year:

2001

File:

PDF, 26 KB

2001

9

Synthesis of 1,4-Anhydro-2-deoxy-D-ribitol Derivatives from Thymidine Using Improved Preparation of Furanoid Glycals.

Vladimir Serebryany, Alexander Karpeisky, Jasenka Matulic-Adamic, Leonid Beigelman

Journal:

Year:

2003

File:

PDF, 90 KB

2003

10

Scalable and Efficient Synthesis of 2′-Deoxy-2′-N-phthaloyl Nucleoside Phosphoramidites for Oligonucleotide Synthesis.

Alexander Karpeisky, David Sweedler, Peter Haeberli, Javier Read, Keith Jarvis, Leonid Beigelman

Journal:

Year:

2003

File:

PDF, 215 KB

2003

11

Synthesis and Enzymic Hydrolysis of Oligoribonucleotides Incorporating 3-Deazaguanosine: The Importance of the Nitrogen-3 Atom of Single Conserved Guanosine Residues on the Catalytic Activity of the Hammerhead Ribozyme.

Frank Seela, Harald Debelak, Lori Andrews, Leonid Beigelman

Journal:

Year:

2003

File:

PDF, 54 KB

2003

12

Synthesis and Enzymic Hydrolysis of Oligoribonucleotides Incorporating 3-Deazaguanosine: The Importance of the Nitrogen-3 Atom of Single Conserved Guanosine Residues on the Catalytic Activity of the Hammerhead Ribozyme

Frank Seela, Harald Debelak, Lori Andrews, Leonid Beigelman

Journal:

Helvetica Chimica Acta

Year:

2003

Language:

english

File:

PDF, 223 KB

english, 2003

13

Synthesis of 1-deoxy-1-C-(p-Aniline)-β-D-ribofuranose and its incorporation into hammerhead ribozymes

Jasenka Matulic-Adamic, Leonid Beigelman

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 225 KB

english, 1996

14

Optimization of the multiple enzymatic activities of the hepatitis C virus NS3 protein

Shawn Misialek, Ravi Rajagopalan, Sarah K. Stevens, Leonid Beigelman, Scott D. Seiwert, Karl Kossen

Journal:

Analytical Biochemistry

Year:

2009

Language:

english

File:

PDF, 294 KB

english, 2009

15

HCV NS5B polymerase inhibitors 3: Synthesis and in vitro activity of 3-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives

Guangyi Wang, Laiguo Zhang, Xiaomin Wu, Debasis Das, Donald Ruhrmund, Lisa Hooi, Shawn Misialek, P.T. Ravi Rajagopalan, Brad O. Buckman, Karl Kossen, Scott D. Seiwert, Leonid Beigelman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 371 KB

english, 2009

16

Improved Synthetic Approaches Toward 2′-O-Methyl-Adenosine and Guanosine and Their N-Acyl Derivatives

Leonid Beigelman, Peter Haeberli, David Sweedler, Alexander Karpeisky

Journal:

Year:

2000

Language:

english

File:

PDF, 194 KB

english, 2000

17

An efficient preparation of protected ribonucleosides for phosphoramidite RNA synthesis

Vladimir Serebryany, Leonid Beigelman

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 111 KB

english, 2002

18

An efficient synthesis of the ribozyme–folate conjugate

Jasenka Matulic-Adamic, Mark Sanseverino, Leonid Beigelman

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 73 KB

english, 2002

19

Synthesis of 3-(β-D-ribofuranosyl)-2-fluoropyridine and 3-(β-D-ribofuranosyl)-pyridin-2-one

Jasenka Matulic-Adamic, Leonid Beigelman

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 224 KB

english, 1997

20

Synthesis of 5-(β-D-ribofuranosyl)-pyridin-2-one: A “deletion-modiffied” analogue of uridine

Jasenka Matulic-Adamic, Leonid Beigelman

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 230 KB

english, 1997

21

Highly efficient synthesis of 2′-O-amino nucleosides and their incorporation in hammerhead ribozymes

Alexander Karpeisky, Carolyn Gonzalez, Alex B. Burgin, Leonid Beigelman

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 231 KB

english, 1998

22

Functionalized nucleoside 5′-triphosphates for in vitro selection of new catalytic ribonucleic acids

Jasenka Matulic-Adamic, Andrew T Daniher, Alexander Karpeisky, Peter Haeberli, David Sweedler, Leonid Beigelman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 189 KB

english, 2000

23

Synthesis of 1-deoxy-d-ribofuranose phosphoramidite & the incorporation of abasic nucleotides in stem-loop II of a hammerhead ribozyme

Leonid Beigelman, Alexander Karpeisky, Nassim Usman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 432 KB

english, 1994

24

Scaleable and efficient synthesis of 2′-deoxy-2′-N-phthaloyl nucleoside phosphoramidites for oligonucleotide synthesis

Alexander Karpeisky, David Sweedler, Peter Haeberli, Javier Read, Keith Jarvis, Leonid Beigelman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 120 KB

english, 2002

25

Nuclease resistant hammerhead motif: From ‘5-ribo’ to ‘3-ribo’ model

Jasenka Matulic-Adamic, Andrew T. Daniher, Carolyn Gonzalez, Leonid Beigelman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 242 KB

english, 1999

26

Synthesis and incorporation of 2′-amino acid conjugated nucleotides into ribozymes

Jasenka Matulic-Adamic, Leonid Beigelman, Lech W. Dudycz, Carolyn Gonzalez, Nassim Usman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 236 KB

english, 1995

27

Synthesis of pyridinone ribonucleoside 3′-O-phosphoramidites and their incorporation into oligoribonucleotides

Jasenka Matulic-Adamic, Carolyn Gonzalez, Nassim Usman, Leonid Beigelman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 319 KB

english, 1996

28

Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors

Debasis Das, Jian Hong, Shu-Hui Chen, Guangyi Wang, Leonid Beigelman, Scott D. Seiwert, Brad O. Buckman

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 752 KB

english, 2011

29

In vitro selection of a novel nuclease-resistant RNA phosphodiesterase

Amber Beaudry, James DeFoe, Shawn Zinnen, Alex Burgin, Leonid Beigelman

Journal:

Chemistry & Biology

Year:

2000

Language:

english

File:

PDF, 388 KB

english, 2000

30

A Comparative Study on the Cleavage of Stereoisomeric Uridylyl (3',5')Uridines [D,D-, D,L- and L,D-UPU] by Acid, Base and Metal Ion Catalysts

Satu Mikkola, Sergey N. Mikhailov, Ekaterina Efimtseva, Kari Neuvonen, Mikko Oivanen, Leonid Beigelman, Harri Lönnberg

Journal:

Origins of Life and Evolution of Biospheres

Year:

2002

Language:

english

File:

PDF, 79 KB

english, 2002

31

Synthesis of 3′,5′-Cyclic Phosphate and Thiophosphate Esters of 2′-C-Methyl Ribonucleosides

Anna Leisvuori, Zafar Ahmed, Mikko Ora, Leonid Beigelman, Lawrence Blatt, Harri Lönnberg

Journal:

Helvetica Chimica Acta

Year:

2012

Language:

english

File:

PDF, 220 KB

english, 2012

32

Branch-site selection in a group II intron mediated by active recognition of the adenine amino group and steric exclusion of non-adenine functionalities

Qiaolian Liu, Justin B Green, Arbi Khodadadi, Peter Haeberli, Leonid Beigelman, Anna Marie Pyle

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 514 KB

english, 1997

33

The Structural Basis of Hammerhead Ribozyme Self-Cleavage

James B Murray, Daniel P Terwey, Lara Maloney, Alexander Karpeisky, Nassim Usman, Leonid Beigelman, William G Scott

Journal:

Year:

1998

Language:

english

File:

PDF, 4.14 MB

english, 1998

34

Hammerhead ribozyme engineering

Nassim Usman, Leonid Beigelman, James A McSwiggen

Journal:

Current Opinion in Structural Biology

Year:

1996

Language:

english

File:

PDF, 517 KB

english, 1996

35

Ribozyme Catalysis from the Major Groove of Group II Intron Domain 5

Boyana B Konforti, Dana L Abramovitz, Carlos M Duarte, Alex Karpeisky, Leonid Beigelman, Anna Marie Pyle

Journal:

Year:

1998

Language:

english

File:

PDF, 218 KB

english, 1998

36

Synthesis of N -Acetyl- d -galactosamine and Folic Acid Conjugated Ribozymes

Matulic-Adamic, Jasenka, Serebryany, Vladimir, Haeberli, Peter, Mokler, Victor R., Beigelman, Leonid

Journal:

Bioconjugate Chemistry

Year:

2002

Language:

english

File:

PDF, 127 KB

english, 2002

37

2,2-Disubstituted 4-Acylthio-3-oxobutyl Groups as Esterase- and Thermolabile Protecting Groups of Phosphodiesters

Kiuru, Emilia, Ahmed, Zafar, Lönnberg, Harri, Beigelman, Leonid, Ora, Mikko

Journal:

Journal of Organic Chemistry

Year:

2013

Language:

english

File:

PDF, 747 KB

english, 2013

38

Solid-phase synthesis of 5′-triphosphate 2′-5′-oligoadenylates analogs with 3′-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs

Thillier, Yann, Stevens, Sarah K., Moy, Christabel, Taylor, Joshua, Vasseur, Jean-Jacques, Beigelman, Leonid, Debart, Françoise

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.31 MB

english, 2013

39

Nuclease-Resistant Ribozymes Decrease Stromelysin mRNA Levels in Rabbit Synovium Following Exogenous Delivery to the Knee Joint

Craig M. Flory, Pamela A. Pavco, Thale C. Jarvis, Mark E. Lesch, Francine E. Wincott, Leonid Beigelman, Stephen W. Hunt and Denis J. Schrier

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.18 MB

english, 1996

40

Rescue of Abasic Hammerhead Ribozymes by Exogenous Addition of Specific Bases

Alessio Peracchi, Leonid Beigelman, Nassim Usman and Daniel Herschlag

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.29 MB

english, 1996

41

Moieties in an RNA Promoter Specifically Recognized by a Viral RNA-Dependent RNA Polymerase

Robert W. Siegel, Laurent Bellon, Leonid Beigelman and C. Cheng Kao

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.20 MB

english, 1998

42

Synthesis and Structure of 1-Deoxy-1-phenyl-β- d -ribofuranose and Its Incorporation into Oligonucleotides

Matulic-Adamic, Jasenka, Beigelman, Leonid, Portmann, Stefan, Egli, Martin, Usman, Nassim

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 161 KB

english, 1996

43

Chemically Modified Hammerhead Ribozymes with Improved Catalytic Rates

Burgin, Alex B., Gonzalez, Carolyn, Matulic-Adamic, Jasenka, Karpeisky, Alexander M., Usman, Nassim, McSwiggen, James A., Beigelman, Leonid

Journal:

Year:

1996

Language:

english

File:

PDF, 384 KB

english, 1996

44

2′- O -Methyl Thiomethyl Modifications in Hammerhead Ribozymes

Karpeisky, Alexander, Gonzalez, Carolyn, Burgin, Alex B., Usman, Nassim, Beigelman, Leonid

Journal:

Nucleosides and Nucleotides

Year:

1997

Language:

english

File:

PDF, 205 KB

english, 1997

45

Biodegradable Protections for Nucleoside 5′-Monophosphates: Comparative Study on the Removal of O -Acetyl and O -Acetyloxymethyl Protected 3-Hydroxy-2,2-bis(ethoxycarbonyl)propyl Groups

Ora, Mikko, Taherpour, Sharmin, Linna, Risto, Leisvuori, Anna, Hietamäki, Emilia, Poijärvi-Virta, Päivi, Beigelman, Leonid, Lönnberg, Harri

Journal:

Journal of Organic Chemistry

Year:

2009

Language:

english

File:

PDF, 777 KB

english, 2009

46

Identification of the Hammerhead Ribozyme Metal Ion Binding Site Responsible for Rescue of the Deleterious Effect of a Cleavage Site Phosphorothioate †

Wang, Shenglong, Karbstein, Katrin, Peracchi, Alessio, Beigelman, Leonid, Herschlag, Daniel

Journal:

Year:

1999

Language:

english

File:

PDF, 205 KB

english, 1999

47

Structural Variation Induced by Different Nucleotides at the Cleavage Site of the Hammerhead Ribozyme †

Simorre, Jean-Pierre, Legault, Pascale, Baidya, Narayan, Uhlenbeck, Olke C., Maloney, Lara, Wincott, Francine, Usman, Nassim, Beigelman, Leonid, Pardi, Arthur

Journal:

Year:

1998

Language:

english

File:

PDF, 212 KB

english, 1998

48

The 2,6-Diaminopurine Riboside.cntdot.5-Methylisocytidine Wobble Base Pair: An Isoenergetic Substitution for the Study of G.cntdot.U Pairs in RNA

Strobel, Scott A., Cech, Thomas R., Usman, Nassim, Beigelman, Leonid

Journal:

Year:

1994

Language:

english

File:

PDF, 1.39 MB

english, 1994

49

Site-Specific Cross-Linking of Amino Acids in the Basic Region of Human Immunodeficiency Virus Type 1 Tat Peptide to Chemically Modified TAR RNA Duplexes

Farrow, Mark A., Aboul-ela, Fareed, Owen, David, Karpeisky, Alexander, Beigelman, Leonid, Gait, Michael J.

Journal:

Year:

1998

Language:

english

File:

PDF, 244 KB

english, 1998

50

A Core Folding Model for Catalysis by the Hammerhead Ribozyme Accounts for Its Extraordinary Sensitivity to Abasic Mutations †

Peracchi, Alessio, Karpeisky, Alexander, Maloney, Lara, Beigelman, Leonid, Herschlag, Daniel

Journal:

Year:

1998

Language:

english

File:

PDF, 235 KB

english, 1998

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